Researchers profile 25 million cells to build the most detailed basal ganglia map
A collaboration mapped cell types of the basal ganglia, a region linked to psychiatric and neurological disorders, and found a new neuron type possibly tied to schizophrenia.
A large scientific collaboration has produced the most detailed map of the basal ganglia to date, ua.news reports, citing STAT News. The basal ganglia are a brain region linked to a range of psychiatric and neurological disorders. Researchers profiled more than 25 million cells. ua.news
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The data allowed the team to compile a list of cell types present in the basal ganglia and describe where they are located. The scientists also identified a new type of neuron that may play a role in schizophrenia.
They found cell types associated with depression, bipolar disorder and post-traumatic stress disorder. The authors obtained preliminary evidence that a more detailed understanding of brain cell types may help make therapy more precise.
In mouse models of Parkinson's disease, a gene therapy developed for a subgroup of basal ganglia cells was as effective as a broader approach. It also proved safer. ua.news
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