Cells, proteins, enzymes and organisms: discoveries that become technologies.
Updated
Measurements from a research cruise show that Subantarctic Mode Water and Antarctic Intermediate Water enrich in nutrients differently as they move north for decades.
Sequencing of ancient DNA revealed a previously elusive population that entered Sweden by about 4,000 years ago, roughly 800 years later than the traditional date for Germanic's arrival.
Authors found that specific codon pairs cause −1 ribosomal frameshifting mainly in cancer cells and used it to switch on a pyroptosis gene in mouse tumour models.
A correlative X-ray method combining phase-contrast CT and small-angle scattering mapped nano- and microscale strain in intact rat discs under load.
In Drosophila erecta, food volatiles trigger male sexual arousal and start a visual feedback loop across the group. D. melanogaster does not depend on them for courtship.
University of Vienna researchers combined genomes with cave sediment DNA and found long-distance gene flow alongside regional continuity through the Last Glacial Maximum.
Authors analysed genome-wide data from 4,587 ancient individuals against four models of Celtic origin and favour a movement from eastern central Europe as the most parsimonious.
Two Nature studies by a team from Copenhagen and Leiden analysed DNA of over 4,500 ancient individuals; the authors tie migrations to the spread of Germanic and Celtic languages.
In blood samples from 34 patients with systemic lupus erythematosus, Nature authors found 271 splicing events absent in controls; peptides from them activated T cells in vitro.
Italian teams (Niguarda, IFOM, INGM) linked early-onset colorectal cancer to reactivated HERVH sequences; in organoids, ATR inhibitors reduced viability. The result is preclinical.
Spanish researchers placed 219 engineered circuits of four types in bacteria and found that chromosomal position alone modulates performance and switches dynamics, via expression noise.
Portuguese and UK groups deleted the EMC3 subunit in mouse and Drosophila tissues. Lipid droplet homeostasis was disrupted and levels of the protein FITM2 fell.
Molecular dynamics of Trp-cage cooled at seven rates, the slowest matching experiment, found small but observable population shifts and a way to correct them.
Authors showed that endosomal Gs/cAMP signaling from one activated receptor outweighs concurrent plasma membrane RhoA activation, and in parathyroid cells suppresses hormone secretion.
Researchers at the Chinese University of Hong Kong compared stool microbiomes of 720 children with ASD and 151 controls. Associations with severity were significant but explained little variance.
In mice, deleting IRE1α or XBP1 in hepatocytes worsened liver metastasis, while the IRE1α inhibitor MKC8866 did not control metastases in the liver.
Bryan Jennings proposes that a change in body size can alter trait proportions before related species compete. The theory draws on measurements of preserved lizards.
Ancient DNA from a man buried at Fallward on the North Sea coast revealed a leprosy pathogen not previously found in Europe, and an origin in the Danube region.
Researchers anchored a TAM-targeted STING nanoagonist to adoptive T cells so that the agonist is activated only where both are present. The results were obtained in mice.
Weill Cornell and Yonsei researchers describe a photocatalytic labeling method that identifies protein–protein interactions in human tissue without model organisms in the first discovery step.
