Russian researchers identify four metabolic subtypes of heart failure in 498-patient study

Russian researchers analyzed blood plasma samples from 498 individuals to identify metabolic variations in cardiovascular pathologies, according to science.mail science.mail.ruscience.mailscience.mail.ruOpen source ↗. The cohort included 218 patients with chronic heart failure, 108 with arterial hypertension, 89 with ischemic heart disease, and 83 healthy volunteers.

The specialists examined 93 metabolites and detected statistically significant variations across 25 compounds between the subject groups. Based on these biochemical profiles, the team categorized chronic heart failure into four distinct metabolic subtypes, each exhibiting specific clinical manifestations and differing prognoses.

This biochemical profiling enables more precise disease classification than traditional evaluations based solely on clinical stage and left ventricular ejection fraction. The authors noted that testing plasma metabolite levels could help clinicians assess complication risks and adjust therapeutic strategies.