细胞、蛋白质、酶与生物体：正在变成技术的发现。
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Authors mapped a main calpain cleavage site in TBP, the protein mutated in spinocerebellar ataxia type 17, and linked its fragments to AMOT; tested in cells, rat and zebrafish.
Monkeys trained to produce a set number of actions showed a systematic bias toward stopping early. The authors explain it with an accumulation-to-bound model of termination.
In mice, the transcriptional regulator IκBζ controls cytokine production and proliferation of ILC2 cells. Without it, hookworm clearance is delayed and airway inflammation is reduced.
In a 50-adult Phase 2a challenge study, one dose of ETH47, an mRNA encoding interferon lambda, gave numerical reductions in rhinovirus load and symptoms; no p-values were reported.
Biogen's litifilimab kept improving skin clearance through 52 weeks in the AMETHYST Phase 2/3 trial in cutaneous lupus, per data presented at ACR Convergence 2026.
The Guizhou forestry bureau reported a new species of the genus Scincella from the Kuankuoshui and Dashahe reserves; the work appeared in Zoosystematics and Evolution.
Researchers compared unvoiced calls such as acoustic raspberries in 91 chimpanzees. Groups with adult role models used them in one stable context; groups without them did not.
In a retrospective study of 91,941 pregnant women, first-trimester thyroid hormone levels were nonlinearly associated with liver enzyme abnormalities. Their co-occurrence was linked to later complications.
Researchers from the Japan Institute for Health Security and Tohoku University found the cell-surface protein that lets rubella virus enter airway and placental cells.
In a phase I trial in 10 healthy adults, injected volar fibroblasts increased skin thickness and elasticity at treatment sites. The approach is studied for amputees' residual limb skin.
FITdb integrates 43 screens covering 20,696 mouse and 22,293 human genes across 199 immune cell types and states. Researchers can query how gene perturbation affects immune cell function.
In mice, loss of CASS4 left microglia unable to contain amyloid-beta plaques, which grew and spread faster. The authors propose the gene as a biomarker and a therapeutic target.
Authors of a review of more than 350 studies report that, for many people, excess protein may bring no benefit and may interfere with longevity. They say protein needs are individual.
Researchers also recorded fewer calves and more entanglements; Olaf Meynecke says early sea ice melt and less food may be factors.
In a field study of 77 redwoods burned in the 2020 CZU Lightning Complex, basal resprouting did not decline with greater fire damage but increased. Drier sites showed less.
A review in BMC Infectious Diseases found 144 serum and plasma biomarkers that differed between Long COVID patients and controls. IL-6, TNF-α, IL-1β and CRP were most often elevated.
Analysis of 27 wastewater samples from nine treatment plants in 2022 found gut bacteria profiles that varied by city and were associated with local health and social data.
In the randomized DAPARHT trial, dapagliflozin 10 mg gave a more favorable eGFR slope than placebo over 12 months. Kidney disease is common after heart transplantation.
Authors of a Current Biology study modelled over 8,000 North American fossils and found detection odds fell while habitat occupancy stayed stable for four dinosaur clades.
Fecal DNA from seven islands gave the first peer-reviewed coyote population estimate for any barrier island: 45–61 animals per season, despite removals.
