脑机接口、神经假体与大脑研究。
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Authors mapped a main calpain cleavage site in TBP, the protein mutated in spinocerebellar ataxia type 17, and linked its fragments to AMOT; tested in cells, rat and zebrafish.
Monkeys trained to produce a set number of actions showed a systematic bias toward stopping early. The authors explain it with an accumulation-to-bound model of termination.
A cross-sectional study of 28,118 older adults in Japan linked back or leg pain-related restriction of going out to higher odds of limitation in daily tasks such as shopping and paying bills.
In a randomized trial in India, healthy adults practicing a standardized yoga protocol for 45 days showed better affect and sleep; fMRI showed altered connectivity in several brain networks.
In a 4-arm bandit task with prefrontal fNIRS recording, non-kleptomanic theft recidivists updated action values more slowly than controls, the authors report.
In UK Biobank data on 22,618 adults, short bouts of vigorous everyday movement went with lower dementia rates over about eight years. The evidence is observational.
In mice, loss of CASS4 left microglia unable to contain amyloid-beta plaques, which grew and spread faster. The authors propose the gene as a biomarker and a therapeutic target.
In a cohort of 73,413 UK Biobank participants, wrist-sensor gait measures differed in 314 people later diagnosed with Parkinson's disease, years before diagnosis.
In experiments on 30 male and 27 female mice, testosterone affected the choice of warm surfaces; the authors link it to signal transmission, not thermoregulation.
In a retrospective Mayo Clinic study of 137 leads, awake surgery led to repositioning in about 15%; 88% of those changes could not have been made by imaging alone.
Hamburg researchers found that the protein RIPK1 contributes to damage of brain vascular cells in malaria-infected mice. Human tissue and genetic data point to it as well.
A Nature Communications study found that PMDD follows no single pattern: three subtypes differ in when symptoms start, peak and how severe they are. The authors hope for more individualised monitoring.
Researchers found that a chimpanzee-specific retroviral insertion keeps the LINC00662 gene silent, while it stays active in human brain organoids and supports neuronal development.
Authors of a review of Mendelian randomization studies found inconsistent genetic evidence for general activity and mental disorders, and more consistent data for fitness measures such as grip strength.
Stanford researchers built the ARC scale from resting-state brain activity. In a cohort of 1,300+ healthy adults it was linked to faster cognitive decline, before memory differences appeared.
A pooled analysis of 61 cohort studies with about 2.8 million participants links current smoking to higher risk of all-cause, Alzheimer's and vascular dementia, rising with cigarettes per day.
In mice, glioma cells capture the NLGN3 protein released by active neurons via CSPG4 and divide faster; disrupting this link slowed tumor growth.
Participants in a Lancaster University study estimated about 37 phone checks per day, but measurement showed about 85 on average. An applied-neuroscience expert links such interruptions to lost focus.
Slow brain waves in deep sleep were flatter and lower in people with abnormal amyloid markers but no cognitive impairment, which may point to a non-invasive marker of preclinical disease.
Researchers at IR Sant Pau found elevated neurofilament light chain in carriers of the Huntington's mutation before symptoms or brain atrophy. Current staging criteria cannot distinguish these cases.
