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Authors mapped a main calpain cleavage site in TBP, the protein mutated in spinocerebellar ataxia type 17, and linked its fragments to AMOT; tested in cells, rat and zebrafish.
In mice, the transcriptional regulator IκBζ controls cytokine production and proliferation of ILC2 cells. Without it, hookworm clearance is delayed and airway inflammation is reduced.
A cross-sectional study of 28,118 older adults in Japan linked back or leg pain-related restriction of going out to higher odds of limitation in daily tasks such as shopping and paying bills.
In an emulated cohort study of real-world US data, patients with ASCVD and elevated LDL-C on statins had fewer heart attacks over four years with evolocumab than with ezetimibe.
In a secondary analysis of the EAST-AFNET-4 trial, patients with recent atrial fibrillation and chronic kidney disease had fewer cardiovascular events under early rhythm control.
In a randomized trial in India, healthy adults practicing a standardized yoga protocol for 45 days showed better affect and sleep; fMRI showed altered connectivity in several brain networks.
In the BE BOLD Phase 3b trial of 553 adults with psoriatic arthritis, numerically greater ACR50 rates for BIMZELX held from Week 16 through Week 24, UCB reported.
In a 50-adult Phase 2a challenge study, one dose of ETH47, an mRNA encoding interferon lambda, gave numerical reductions in rhinovirus load and symptoms; no p-values were reported.
Biogen's litifilimab kept improving skin clearance through 52 weeks in the AMETHYST Phase 2/3 trial in cutaneous lupus, per data presented at ACR Convergence 2026.
In a 4-arm bandit task with prefrontal fNIRS recording, non-kleptomanic theft recidivists updated action values more slowly than controls, the authors report.
In a retrospective study of 91,941 pregnant women, first-trimester thyroid hormone levels were nonlinearly associated with liver enzyme abnormalities. Their co-occurrence was linked to later complications.
Researchers from the Japan Institute for Health Security and Tohoku University found the cell-surface protein that lets rubella virus enter airway and placental cells.
In a small Phase 2 trial, four monthly doses of PepGen's experimental drug for myotonic dystrophy type 1 repaired splicing errors in six patients; the company's shares rose over 90%.
A scoping review of 1,145 records found that hearing technologies improved communication outcomes and reduced participation limits in older adults, while effects on loneliness were mixed.
In UK Biobank data on 22,618 adults, short bouts of vigorous everyday movement went with lower dementia rates over about eight years. The evidence is observational.
In a phase I trial in 10 healthy adults, injected volar fibroblasts increased skin thickness and elasticity at treatment sites. The approach is studied for amputees' residual limb skin.
FITdb integrates 43 screens covering 20,696 mouse and 22,293 human genes across 199 immune cell types and states. Researchers can query how gene perturbation affects immune cell function.
A meta-analysis of 28 studies with 1,918,120 participants found statin therapy insufficient to protect against AMD; the authors advise against prescribing statins specifically for it.
In mice, loss of CASS4 left microglia unable to contain amyloid-beta plaques, which grew and spread faster. The authors propose the gene as a biomarker and a therapeutic target.
Authors of a review of more than 350 studies report that, for many people, excess protein may bring no benefit and may interfere with longevity. They say protein needs are individual.
