# Surrey trial: NOVOS Core supplement improved vascular markers in 61 participants over six months

- Published: 2026-11-05 01:25 UTC
- Section: Life & Health › Biology & biochemistry
- Tags: NOVOS Core, University of Surrey, randomised controlled trial, flow-mediated dilation, pulse wave velocity, systolic blood pressure, arterial stiffness, endothelial function, ageing biology, European Heart Journal Open
- URL: https://realtech.media/news/rt-9e4e1b71884e159bd874c5ce_surrey_trial_novos/

**In a randomised placebo-controlled trial, a multi-component supplement improved endothelial function, arterial stiffness and systolic pressure; these are biomarkers, not clinical outcomes.**

![Surrey trial: NOVOS Core supplement improved vascular markers in 61 participants over six months](https://sgzwpqqelzmajkcubgkl.supabase.co/storage/v1/object/public/rt-media/2026/11/dba2b6919784258f.jpg)
*CNEcija12345, Wikimedia Commons, CC BY-SA 4.0*

Researchers at the University of Surrey report that a multi-component nutritional supplement, NOVOS Core, improved markers of vascular health in a randomised controlled trial, according to surrey.ac.uk. The trial enrolled 61 participants: 33 received the supplement and 28 a placebo, taken once daily for six months. [1] The results were published in European Heart Journal Open. [1]

The formulation combines vitamins and minerals, amino acids and plant-derived bioactives, chosen for their relevance to several biological processes associated with ageing. The Surrey team tested whether targeting several of these processes at once could influence cardiovascular biomarkers. These measures capture complementary aspects of vascular health and are associated with cardiovascular risk, but they are not clinical outcomes. [1]

## Vascular measures in the trial

Flow-mediated dilation, a measure of endothelial function (regulation of blood vessel tone and blood clotting), improved in the supplement group compared with controls. An improvement was also seen one hour after the first dose, while values in the control group stayed largely unchanged. [1]

At six months the adjusted between-group difference in systolic blood pressure was 6.1 mmHg in favour of the supplement group, and a difference was also observed one hour after the first dose. Pulse wave velocity, a measure of arterial stiffness, was lower in the supplement group, with an adjusted between-group difference of 1.18 m/s. [1]

## Context and limitations

Blood tests showed no significant changes in cholesterol or other blood lipids, which, according to the authors, suggests the vascular changes were not explained by lipid lowering. The estimated 10-year cardiovascular risk decreased modestly, largely reflecting the difference in systolic pressure. [1]

The release notes that previous large studies associated a sustained 5 mmHg reduction in systolic pressure with an approximately 10 percent reduction in major cardiovascular events. The present study was not designed to assess clinical outcomes. [1]

Diogo Barardo, Director of R&D at NOVOS, said development of the formulation began in 2019 on the hypothesis that targeting the hallmarks of ageing simultaneously could produce measurable improvements in affected organs and systems. Professor Juliet Wright, Founding Dean of the School of Medicine at Surrey, called the findings an interesting proof of concept. She said the next steps are to understand the underlying biology and to establish whether the biomarker changes translate into longer-term health benefits. [1]

## Sources

1. [surrey.ac.uk](https://www.surrey.ac.uk/news/targeting-multiple-ageing-related-processes-nutritional-supplement-shows-promising-effects-vascular)
2. [Medical Xpress](https://medicalxpress.com/news/2026-11-supplement-aging-potential-markers-blood.html)

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Source: RealTech, realtech.media — https://realtech.media/news/rt-9e4e1b71884e159bd874c5ce_surrey_trial_novos/