# Ketogenic diet reduced liver fat by 67 percent in trial with 42 patients

- Published: 2026-11-07 00:28 UTC
- Section: Life & Health › Medicine
- Tags: ketogenic diet liver fat, prediabetes dietary intervention, Washington University School of Medicine, liver steatosis clinical trial, Mediterranean diet liver fat
- URL: https://realtech.media/news/rt-4079d2b97d0f13a0acd9562e_ketogenic_diet_reduced/

**In a clinical trial on adults with obesity and prediabetes, a ketogenic diet cut liver fat by 67 percent despite equal weight loss.**

![Ketogenic diet reduced liver fat by 67 percent in trial with 42 patients](https://realtech.media/media/2026/11/275e4ae7ea48115c.jpg)
*lomazoma.com*

In a randomized clinical trial, participants on a ketogenic diet reduced their liver fat content by an average of 67 percent from baseline, according to lomazoma.com [1]. For comparison, participants on a Mediterranean diet and a low-fat, predominantly plant-based diet showed an average reduction of 45 percent each [1]. Across all three groups, participants lost approximately 10 percent of their initial body weight [1]. The findings apply to individuals who simultaneously present with obesity, prediabetes, and fatty liver disease [1].

## Trial design and dietary protocols

The trial initially randomized 55 adults into one of three dietary regimens, and 42 participants completed the intervention [1]. Over four to five months, the research team provided all meals to the participants, adjusting caloric intake so that weight loss remained comparable across all cohorts [1]. The ketogenic diet provided 4 percent of calories from carbohydrates and 73 percent from fat, inducing the body to use fat and ketone bodies as primary energy sources [1]. Blood lipids and cholesterol levels in the ketogenic group did not rise despite the high dietary fat content [1].

## Metabolic outcomes and body composition

Metabolic outcomes differed between the groups following weight reduction. In the ketogenic group, about half of the participants no longer met diagnostic criteria for prediabetes at the end of the study, compared to 29 percent in the Mediterranean group and 7 percent in the low-fat group [1]. Insulin sensitivity improved across all groups, with liver metabolism showing marked changes under the ketogenic protocol [1]. However, the Mediterranean diet showed advantages in body composition, leading to greater body fat loss and smaller reductions in fat-free mass [1]. Study author Samuel Klein from Washington University School of Medicine noted that reducing carbohydrate intake provides metabolic effects beyond weight loss [1].

## Sources

1. [lomazoma.com](https://lomazoma.com/fettleber-diaet-gleicher-gewichtsverlust-aber-67-prozent-weniger-leberfett-mit-keto)

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Source: RealTech, realtech.media — https://realtech.media/news/rt-4079d2b97d0f13a0acd9562e_ketogenic_diet_reduced/