# Russian researchers identify four metabolic subtypes of heart failure in 498-patient study

- Published: 2026-11-07 15:07 UTC
- Section: Life & Health › Medicine
- Tags: heart failure metabolic types, plasma metabolites, cardiovascular diagnostics, chronic heart failure, metabolite profiling
- URL: https://realtech.media/news/rt-26c3adef4dc3332aa9b4356a_russian_researchers_identify/

**Analysis of 93 blood metabolites revealed distinct disease profiles that refine traditional risk and progression assessment.**

![Russian researchers identify four metabolic subtypes of heart failure in 498-patient study](https://realtech.media/media/2026/11/7a8f48e1381073e3.jpg)
*science.mail*

Russian researchers analyzed blood plasma samples from 498 individuals to identify metabolic variations in cardiovascular pathologies, according to science.mail [1]. The cohort included 218 patients with chronic heart failure, 108 with arterial hypertension, 89 with ischemic heart disease, and 83 healthy volunteers [1].

The specialists examined 93 metabolites and detected statistically significant variations across 25 compounds between the subject groups [1]. Based on these biochemical profiles, the team categorized chronic heart failure into four distinct metabolic subtypes, each exhibiting specific clinical manifestations and differing prognoses [1].

This biochemical profiling enables more precise disease classification than traditional evaluations based solely on clinical stage and left ventricular ejection fraction [1]. The authors noted that testing plasma metabolite levels could help clinicians assess complication risks and adjust therapeutic strategies [1].

## Sources

1. [science.mail](https://science.mail.ru/news/59901-v-rossii-otkryili-novyij-metod-lecheniya-serdechnoj-nedostatochnosti)

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Source: RealTech, realtech.media — https://realtech.media/news/rt-26c3adef4dc3332aa9b4356a_russian_researchers_identify/