# Enamel proteins from six Homo erectus teeth, about 0.4 million years old, analysed in China

- Published: 2026-11-05 17:32 UTC
- Section: Life & Health › Biology & biochemistry
- Tags: Homo erectus, enamel proteins, Middle Pleistocene, AMBN, Denisovans, Zhoukoudian, Hexian, Sunjiadong, amino acid variants, human evolution
- URL: https://realtech.media/news/rt-0db6ce8d3185a5e1398604e5_enamel_proteins_from/

**Proteins from teeth of six Homo erectus individuals from three Chinese sites show two shared amino acid variants, one of them previously unknown.**

![Enamel proteins from six Homo erectus teeth, about 0.4 million years old, analysed in China](https://sgzwpqqelzmajkcubgkl.supabase.co/storage/v1/object/public/rt-media/2026/11/0836330142caa1d2.png)
*nature.com*

Researchers extracted and analysed ancient enamel proteins from six Middle Pleistocene Homo erectus teeth, from five male and one female individual, found at the Zhoukoudian, Hexian and Sunjiadong sites in China, according to a paper on nature.com. The specimens date to approximately 0.4 million years ago [1]. The only molecular data previously recovered from H. erectus were peptides from a 1.77-million-year-old tooth from Dmanisi, Georgia, and those sequences lacked single amino acid polymorphisms that distinguish H. erectus from other human lineages [1].

## Specimens and sites

The Zhoukoudian tooth (PA69) comes from layers 8–9, dated to 0.42 million years, and was found between 1949 and 1951. Two teeth come from the Hexian site in Anhui Province, southern China (0.41 million years), and three from Sunjiadong in Henan Province, northern China (around 0.4 million years) [1]. Taken together, the six samples are roughly contemporary and represent individuals from both northern and southern China. The authors also included a tooth from a Denisovan skull from Harbin, China, with a minimum age of 0.15 million years [1].

The Hexian remains are morphologically closer to the Indonesian Java fossils than to those from Zhoukoudian, while the Nanjing and Sunjiadong fossils resemble the Zhoukoudian material [1].

## Shared amino acid variants

All specimens from all three sites share two amino acid variants [1]. One of them, A253G in the AMBN protein, was previously unknown. It has not been found in H. erectus from Dmanisi, in Homo antecessor from Atapuerca, in Denisovans, in Neanderthals or in modern humans [1].

The other variant, AMBN M273V, had been identified earlier in Denisovans. The authors say the new evidence indicates it may have been introduced through populations related to these Middle Pleistocene H. erectus [1]. They also conclude that regions of the Denisovan genome attributed to super-archaic introgression, some of which later passed to modern humans, are likely to have originated from H. erectus [1].

According to the authors, late Middle Pleistocene H. erectus may have coexisted with Denisovans in parts of East Asia, where these interactions are presumed to have occurred [1]. A ScienceDaily summary of the study adds that the corresponding variant occurs in living people at 21% in the Philippines and about 1% in India.

## Sources

1. [nature.com](https://www.nature.com/articles/s41586-026-10478-8)
2. [ScienceDaily](https://www.sciencedaily.com/releases/2026/11/261102202836.htm)

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Source: RealTech, realtech.media — https://realtech.media/news/rt-0db6ce8d3185a5e1398604e5_enamel_proteins_from/